Is azelaic acid flammable?

This blog post will answer the question, “Is azelaic acid flammable” covering topics like the flammability of azelaic acid and frequently asked questions related to the topic.

Is azelaic acid flammable?

No, Azelaic acid is not flammable. 

Rosacea-related pimples are treated with azelaic acid topical (for the skin). The topical use of azelaic acid may not be beneficial in the treatment of skin redness.

Azelaic acid topical can also be used for other things that aren’t covered in this medication guide.

Warnings(while using azelaic acid topical)

  • Only use as indicated. If you’re taking any other medications or have any other medical issues or allergies, tell your doctor.
  • Before you start taking any medication, make sure you have everything you need.
  • If you are sensitive to azelaic acid or propylene glycol, you should avoid using azelaic acid topical.
  • If you’ve ever had asthma, tell your doctor.
  • If you’re pregnant or nursing, let your doctor know.
  • If you’re breastfeeding, don’t use this drug on your nipple.
  • Anyone under the age of 18 is not permitted to use this product.

What is the best way to apply azelaic acid to my skin?

Read any drug guides or instructions papers and follow all guidelines on your prescription label. Follow the medication’s instructions to the letter.

  • Do not take this medication by mouth. Topical medication is only meant to be applied to the skin.
  • Before and after using this drug, wash your hands.
  • Before each usage, give the foam a good shake.
  • Clean the afflicted area with a gentle cloth and a little soap or soap-free cleaning lotion. Follow the medication’s instructions exactly.
  • Do not use it on sunburned, dry, chapped, sensitive, or damaged skin.
  • Unless your doctor instructs you otherwise, do not cover the cured skin area with a bandage.
  • It’s possible that your symptoms won’t improve for up to four weeks. If your symptoms do not improve after twelve weeks of medication, see your doctor.
  • Severe burning, roughness, or skin irritation should be reported to your doctor.
  • Store away from moisture and heat at room temp. 8 weeks after opening, discard the foam.
  • Topical azelaic acid foam is combustible. Avoid using near a source of strong heat or an open flame. Wait until the gel has fully dried on your skin before smoking.

When taking azelaic acid topical, what should I avoid?

If azelaic acid topical gets into your nose, eyes, mouth, rectum, or vaginal area, rinse with water. If you have persistent discomfort after putting this drug in your eyes, contact your doctor.

Unless your doctor advises you otherwise, avoid using other drugs on the areas you’re treating with azelaic acid topical.

Avoid strong soaps or skin cleansers, as well as products containing alcohol, spices, exfoliants, or lime, which may irritate the skin.

During therapy with azelaic acid topical, your doctor may advise you to avoid spicy meals, hot foods or drinks, alcoholic beverages, and other foods or beverages that may promote flushing or redness of the skin.

Topical azelaic acid side effects

If you experience hives, difficulty breathing, or swelling of your cheeks, lips, tongue, or neck, get immediate medical attention.

If you have: Stop taking this drug and see your doctor right away if you have:

  • Intense stinging, burning, or heat;
  • Itchiness or tingling in the extremities;
  • Extreme irritation (redness, dryness, peeling, etc. );
  • Skin color changes; or
  • Breathing difficulties that are new or intensifying.

The following are some of the most common negative effects:

  • A scorching, stinging, or tingling sensation;
  • Skin that is dry or scaly;
  • Irritation from itching or anything else.

Azelaic acid  (First-Aid Measures)

First-aid procedures are described.

Advice in general:

Remove contaminated garments as soon as possible.

If inhaled, it may cause:

If complications arise after inhaling dust, get some clean air and seek medical help.

If used on the skin:

Using soap and water, thoroughly clean the area. Dispose of any infected clothes. Seek medical help if inflammation develops.

If it’s in your eyes:

With the eyelids open, wash the afflicted eyes for at least 10 min under running water. Seek medical help if inflammation develops.

If ingested:

Do not provoke vomiting and seek medical assistance immediately after rinsing your mouth and drinking 200-300 mL of water. If the person is unconscious or having difficulty breathing, never force vomiting or administer anything by mouth.

Fire controlling measures of azelaic acid

Extinguishing media suitable for the job:

  • Water spray, dry powder, foam, co2
  • Extinguishing media that aren’t safe to use:
  • Carbon dioxide

Additional Information:

Because of the risk of dust explosion, avoid spinning up the material/product.

During firefighting, there are many dangers to be aware of:

  • Burning emits poisonous and deadly gases.

Firefighting protective equipment:

  • Wear breathing equipment that is self-contained.

Measures for unintentional release of azelaic acid

Dust should not be dispersed in the air (i.e., clearing dust surfaces with compressed air). Avoid the production and accumulation of dust, since this might lead to a dust explosion. When dust is present in high enough concentrations, it may create an explosive combination in the air. Handle with care to avoid dusting and to keep open flames and other sources of fire at bay.

Personal safety measures, protective gear, and emergency plans

Dust should be avoided at all costs. Wear personal protective equipment. Avoid coming into touch with your skin and eyes.

Environmental safeguards

Keep polluted water/firefighting water contained. Drains, surface waterways, and groundwater should not be used.

Storage and Handling

Safe-handling precautions

Containers that have been sealed must only be opened in well-ventilated places.

Anti-incendiary and anti-explosion protection:

Dust should be avoided at all costs. When dust is present in high enough concentrations, it may create an explosive combination in the air. Handle with care to avoid dusting and to keep open flames and other sources of fire at bay. Dust should not gather on surfaces if housekeeping is done on a regular basis. When dry particles are exposed to the friction of transfer and mixing activities, static electrical charges may form. Provide necessary safeguards, such as electrical grounding and bonding, as well as inert environments. 

Any incompatibilities, as well as the conditions for safe storage

Low-density polyethylene is a good material for containers (LDPE)

Personal Protection/Exposure Controls

System design advice:

It is suggested that any dust control equipment used in the handling of this product, such as local exhaust ventilation and materials transport systems, include explosion relief vents, an explosion suppression system, or an oxygen-deficient atmosphere. Ascertain that dust-handling systems (such as exhaust vents, dust collectors, containers, and processing equipment) are constructed in such a way that dust does not escape into the workspace (i.e., there is no leakage from the equipment). Only use electrical equipment and motorized industrial vehicles that are properly categorized.

Personal safety equipment (PPE)

Protection for the lungs:

If required, use a NIOSH-certified (or comparable) respirator.

Protection for the hands:

Wear chemically impermeable protective gloves.

Protection for the eyes:

If there is a risk of airborne dust exposure, use safety eyewear (chemical goggles).

Protection for the body:

The degree of activity and exposure must be taken into consideration while selecting body protection.

What is the right way to apply azelaic acid topical?

It is critical that you take this medication exactly as prescribed. Do not take more of it, take it more often, or take it for longer than your doctor prescribed. It’s possible that this may irritate your skin.

This drug should only be applied to the skin. It should not come into contact with your nose, eyes, mouth, or vaginal area. If it gets on these places, immediately rinse it off with water and see your doctor, particularly if you have red, irritated eyes.

It’s essential that you use this drug for the whole treatment period if you want to get rid of your acne or rosacea entirely. Make sure you don’t skip any doses.

To avoid further skin irritation, avoid using alcoholic cleansers, tinctures, and astringents, as well as abrasives and peeling chemicals with the foam or gel.

While using the gel, avoid spicy meals, thermally hot foods and drinks (e.g., hot coffee, tea), and alcoholic beverages.

The foam is combustible. When applying the drug and immediately thereafter, stay away from fire, flame, and smoking.

To use the cream, froth, or gel, follow these steps:

  • Before and after taking this drug, wash your hands with water and soap.
  • Wash the afflicted area of your skin with fresh water and a light soap or a soap-free washing lotion before application. Wash well and pat dry.
  • Before using, give the foam can a good shake.
  • Gently massage a tiny bit of the medication into each afflicted region.
  • After the foam or gel has dried, you may apply cosmetics.
  • Unless your doctor instructs you to do so, do not bandage or otherwise wrap the skin that is being treated.

Precautions

  • It’s critical that your doctor monitors your progress at frequent intervals for any possible side effects from this medication.
  • Consult your doctor if your acne does not clear up after four weeks or worsens.
  • Consult your doctor if your redness does not improve after 12 weeks or if it worsens.
  • While using this medication, you may get hypopigmentation. If your skin tone is lighter in the treated regions, see your doctor very once, particularly if you have dark skin.
  • This medication may trigger allergic responses, such as angioedema, which may be fatal and need rapid medical intervention. If you experience itchy skin, difficulties breathing, or massive, hive-like swelling on your face, eyelids, lips, tongue, neck, hands, legs, feet, or sexual organs after taking this prescription, call your doctor straight away.
  • This medication has the potential to induce skin reactions. If you develop a skin rash, burning, redness, flaking, stinging, swelling, or irritation, see your doctor straight once.

Frequently Asked Questions(FAQs), “Is azelaic acid flammable?”

Is azelaic acid heat-sensitive?

Store away from water and heat at room temperature. 8 weeks after opening, discard the foam. Topical azelaic acid foam is combustible. Avoid using near a source of strong heat or an open flame.

What is azelaic acid made from?

Azelaic acid is a saturated dicarboxylic acid found in wheat, maize, and barley that occurs naturally. Malassezia furfur, also known as Pityrosporum ovale, a fungus often found on human skin, also produces it.

Is niacinamide or azelaic acid better?

Both are antioxidants, anti-inflammatory, and antimicrobial, but azelaic acid also serves as a gentle exfoliator, unlike niacinamide. Because of its capacity to improve your skin barrier, niacinamide may be somewhat better for drier skin than azelaic acid.

Is azelaic acid-stable?

Test of physical stability

These findings demonstrate that there is no fragrance change, homogeneity, or color change during storage. This suggests that whether kept at low, room, or high temperatures, azelaic acid cream is physically stable.

Is azelaic acid better than retinol?

In a comedonal acne research, 20 percent azelaic acid cream was just as effective as 0.05 percent tretinoin cream in reducing the number of comedones and improving overall response. However, the azelaic acid gel was better tolerated than topical retinoid, having fewer local adverse effects.

Can I use niacinamide with azelaic acid?

Yes, you may combine niacinamide with azelaic acid; their effects complement each other (and neither deactivates the other). Is it better to take niacinamide before or after taking azelaic acid? Use the Niacinamide before the Azelaic Acid for the greatest effects.

References:

https://documents.basf.com/c7d085a28ec33498c43034dbab2568d9433e1a05#:~:text=Azelaic%20acid%2C%20crude,-Revision%20date%20%3A%202018&text=May%20form%20combustible%20dust%20concentration,H319%20Causes%20serious%20eye%20irritation.
https://www.caymanchem.com/msdss/23977m.pdf
https://www.fishersci.com/store/msds?partNumber=AC401520250&productDescription=AZELAIC+ACID%2C+98%25+25GR&vendorId=VN00032119&countryCode=US&language=en
https://www.parchem.com/siteimages/Attachment/GHS%20Azelaic%20Acid%20MSDS.pdf
https://pubchem.ncbi.nlm.nih.gov/compound/Azelaic-acid
https://www.goldbio.com/documents/3738/A-960-SDS_(MSDS).pdf
https://azelaic.com/wp-content/uploads/2020/06/msds_Azelaic_Acid_-_Uk.pdf

http://hmdb.ca/system/metabolites/msds/000/000/702/original/HMDB00784.pdf?1358893473

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